Endocrine Abstracts

Introduction: HypoPTH is an uncommon disorder, mostly due to anterior neck surgery. The prevalence of HypoPTH has been studied in surgical series and registries, (USA, Denmark and Hungary) where only a minority of patients has HypoPTH due to non-surgical causes. In Spain data on PO HypoPTH in endocrinologist clinical practice has been published recently. The aim of this study was to establish the prevalence of chronic PO HypoPTH in Bilbao area, with a population 2019: 346,843....

Introduction: Intraoperative parathyroid hormone assay (ioPTH) has been validated as a useful tool for predicting postoperative hypocalcaemia (hypoCa) after thyroid surgery and has been proposed as a guide to early discharge from hospital. Its value to predict the risk of future hypoparathyroidism (hypoPT) has not been analyzed in detail. We evaluate this role in our recent surgical series.Description of methods/design: Patients with total thyroidectomy ...

Introduction: Several studies have investigated a possible action of vitamin D metabolites on different lipid fractions but the possible mechanism by which they could act remain unknown, with varying results in observational and intervention studies.Objective: To study the relation between vitamin D levels and lipids levels.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects w...

Background and aims: To assess the relationship between 25-hydroxyvitaminD levels and prevalence and incidence of metabolic syndrome.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects were evaluated. Follow-up visits were performed in 2002–2004 and 2005–2007. At baseline and follow-up, participants underwent an interview and a standardized clinical examination with an oral glucose toleran...

Background and aims: To assess the relationship between obesity and the incidence of hypovitaminosis D and investigate the relationship between 25-hydroxyvitamin D levels and incidence of obesity.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects were evaluated. Follow-up visits were performed in 2002–2004 and 2005–2007. At baseline and follow-up, participants underwent an interview and a...

Introduction: Resistance to thyroid hormones (RTH) is a genetic disorder caused in 85% of cases by mutations in thyroid hormone receptor beta gene (TRβ). The current information about it in Spanish population is scarce, limited to case reports or short series of patients. Thus, we aimed to describe the clinical, biochemical and genetic features of Mediterranean patients with RTH referred to our institution (one of the referral centres in Spain) for genetic testing during ...

It is now widely accepted that the kisspeptins (kps) and their receptor kiss1r play an essential role in the neuroendocrine regulation of the reproductive axis by stimulating hypothalamic GnRH secretion. However, kiss1 and kiss1r expression in tissues distinct from, but related to, the hypothalamus, prompted us to propose that these molecules may exert regulatory functions in additional places of the neuroendocrine system, such as the pituitary and two of its phy...

Ghrelin is a 28-aa peptide originally isolated from stomach but present also in many tissues, including hypothalamus and pituitary, where it stimulates growth hormone (GH) release through the ghrelin/GH secretagogue receptor (GHS-R). Ghrelin also increases food intake and adiposity and could play a key integrative role in the endocrine–metabolic interface. Although its primary pituitary cell target are somatotropes, ghrelin also modulates other pituitary cell types, speci...

Background: Retrospective, transversal and analytical study was designed to determine the relationship between ApoB/ApoA1 ratio, Non-HDL-Cholesterol/HDL-Cholesterol ratio and Metabolic Syndrome (MetS) in type 2 diabetes mellitus (T2DM) patients attending routine follow-up in outpatient clinic from Madrid.Methods: The study was performed at the University Hospital Infanta Leonor, a public health center, and specialized secondary referal, which provides se...

Introduction: Several studies have demonstrated a high incidence of vertebral fractures (VF) in acromegaly, not always correlated with bone mineral density (BMD) value adquired by dual X-ray absorptiometry (DEXA). At trabecular level, GH may alter bone microarchitecture (BM) that predisposes to bone fragility. Trabecular Bone Score (TBS), a textural parameter applied to DEXA to evaluate BM, could be useful to predict VF risk in these patients.Materials a...